The other cancer besides prostate cancer which is exclusive to men is testis cancer. The most common variety, seminoma, is very sensitive to radiation and can be cured 95% of the time with about 3 weeks of treatment. The fields of treatment, however, include a fairly large volume of lymph nodes within the abdominal and pelvic cavities. This can sometimes result in nausea or diarrhea because of the small intestine within the treated volume. Tomotherapy is an excellent way to treat such tumors, while relatively sparing adjacent small bowel.

Both men and women can develop bladder cancer. If this only involves the inside surface of the bladder, surgical removal and/or instillation of chemotherapy within the bladder is very successful. Tumors which have grown into the bladder muscle are much more difficult to control. Sometimes the only potentially curative procedure requires surgical removal of the entire bladder (radical cystectomy). In selected patients, high doses of localized radiation with or without chemotherapy can also result in cure rates comparable to radical cystectomy. With Tomotherapy, it is possible to achieve these high doses, while limiting the side effects from adjacent bowel.