Cancers which arise in bone, muscle, cartilage, or tendon are usually sarcomas. Surgery is the treatment of choice, however, it is often difficult for sarcomas of the trunk to be removed, and sarcomas of the limbs sometimes cannot be removed without amputation. In these situations, 5 or 6 weeks of radiation treatment given before or after a “wide excision” or “limb sparing” procedure can achieve good local control rates. Unfortunately with conventional radiation, bones or large blood vessels adjacent to the tumor can receive enough radiation to potentially damage the limb or bone. Since Tomotherapy can precisely target these tumors, while relatively sparing adjacent structures, it is possible to limit the dosage to bones and blood vessels while treating sarcomas to effective doses. This can be particularly beneficial if long segments of bone or vessels are at risk.